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What Causes Pancreatic Cancer?

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What Causes Pancreatic Cancer?

Postby Lev » Wed Apr 12, 2017 7:37 am

Risk factors for pancreatic cancer include:

Age (particularly over 60)

Male gender

African-American ethnicity

Smoking. Cigarette smoking has a risk ratio of 1.74 with regard to pancreatic cancer; a decade of non-smoking after heavy smoking is associated with a risk ratio of 1.2.

Diets low in vegetables and fruits

Diets high in red meat


Diabetes mellitus

Chronic pancreatitis has been linked, but is not known to be causal

Helicobacter pylori infection

Family history, 5-10% of pancreatic cancer patients have a family history of pancreatic cancer. The genes responsible for most of this clustering in families have yet to be identified. Pancreatic cancer has been associated with the following syndromes; autosomal recessive ataxia-telangiectasia and autosomal dominantly inherited mutations in the BRCA2 geneand PALB2 gene, Peutz-Jeghers syndrome due to mutations in the STK11 tumor suppressor gene, hereditary non-polyposis colon cancer (Lynch syndrome), familial adenomatous polyposis, and the familial atypical multiple mole melanoma-pancreatic cancer syndrome (FAMMM-PC) due to mutations in the CDKN2A tumor suppressor gene.

Gingivitis or periodontal disease.
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