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The cause of low b12 level?

Discuss Lymphoma, Hodgkins Lymphoma, Non-Hodgkins Lymphoma

The cause of low b12 level?

Postby caspar » Mon Nov 12, 2012 2:09 pm

Why would the B12 level drop suddenly in a 55 yr old man with no other health problems?
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The cause of low b12 level?

Postby wiellaford » Mon Nov 12, 2012 2:10 pm

all causes of B12 deficiency anemia (most common) listed in the following:

Inadequate dietary intake (ie, vegetarian diet)

Atrophy or loss of gastric mucosa (eg, pernicious anemia, gastrectomy, ingestion of caustic material, hypochlorhydria, histamine 2 [H2] blockers)

Functionally abnormal IF (IF = intrinsic factor , the factor that is secreted in the GI tract which binds to b12 and helps b12 be absorbed in the intestine)

Insufficient pancreatic protease (eg, chronic pancreatitis, Zollinger-Ellison syndrome)

Bacterial overgrowth in intestine = this will eat away the B12 preventing it from being absorbed adequately

Disorders of ileal mucosa (eg, resection, ileitis, sprue, lymphoma, amyloidosis, absent Intrinsic factor receptor, Zollinger-Ellison syndrome)

Disorders of plasma transport of cobalamin which is b12

Dysfunctional uptake and use of B12 by cells
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The cause of low b12 level?

Postby bailintin » Mon Nov 12, 2012 2:16 pm

all causes of B12 deficiency anemia (most common) listed in the following:

Inadequate dietary intake (ie, vegetarian diet)

Atrophy or loss of gastric mucosa (eg, pernicious anemia, gastrectomy, ingestion of caustic material, hypochlorhydria, histamine 2 [H2] blockers)

Functionally abnormal IF (IF = intrinsic factor , the factor that is secreted in the GI tract which binds to b12 and helps b12 be absorbed in the intestine)

Insufficient pancreatic protease (eg, chronic pancreatitis, Zollinger-Ellison syndrome)

Bacterial overgrowth in intestine = this will eat away the B12 preventing it from being absorbed adequately

Disorders of ileal mucosa (eg, resection, ileitis, sprue, lymphoma, amyloidosis, absent Intrinsic factor receptor, Zollinger-Ellison syndrome)

Disorders of plasma transport of cobalamin which is b12

Dysfunctional uptake and use of B12 by cells
Anemia - B12 deficiency

Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues.

Vitamin B12 deficiency anemia is a low red blood cell count due to a lack of vitamin B12

Your body needs vitamin B12 to make red blood cells. In order to provide vitamin B12 to your cells:

* You must eat enough foods that contain vitamin B12, such as meat, poultry, shellfish, eggs, and dairy products.
* Your body must absorb enough vitamin B12. Your body uses a special protein, called intrinsic factor, released by cells in the stomach. The combination of vitamin B12 attached to intrinsic factor is absorbed in the last part of the small intestine.
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The cause of low b12 level?

Postby davidbeckham » Mon Nov 12, 2012 2:21 pm

Is he on something like Protonix, or other proton pump inhibitor, to lower stomach acid, to reduce the symptoms of reflux?

If so, that can inhibit the body's production of intrinsic factor, which is necessary to absorb the B12.

If not, he needs to consult a gastroenterologist, as that is specialty to address the non-absorption issue.

Also, a strictly vegan diet can do this, but most omnivores have about 10 years of B12 stores in their liver. Therefore, liver dysfunction could also be causative, but again, a gastroenterologist is who takes care of such things.

Best wishes to him, getting that fixed up.
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The cause of low b12 level?

Postby jaedon84 » Mon Nov 12, 2012 2:25 pm

pernicious anaemia, drugs, chrond disease parasitic infections diet (lest likely unless strict vegan)
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