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Is chronic myloid leukemia curable?

Leukemia and blood cancer discussion.

Is chronic myloid leukemia curable?

Postby dakarai37 » Sun Apr 10, 2011 3:38 am

In a 17 year old?I know its different for every person, But generally is it curable?
My friend has it, I haven't really gotten to talk to him or his mom about it yet because they have been so busy but i'm going crazy because I don't know what's going on with him.
So can you just give me info about it? And what is a hickman port?
Thanks!
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Is chronic myloid leukemia curable?

Postby shen21 » Sun Apr 10, 2011 3:45 am

The first couple answers are factually accurate, but likely over your head.

Basically, there are few options for cure, rather management is the route most patients take. Your friend is significantly younger than the avg patient, so a bone marrow transplant could be a more reasonable treatment than for other patients.

A hickman is like a super duper IV. The meds are pretty hard on the body, and can burn the vein. The hickman has tubing that goes through the veins and ends at the top of the heart, so the meds going in the IV dont actually touch the patient's body until it is diluted with all the blood flowing through your heart. It also makes it possible to give the patient a lot of different meds at one time.

In addition, the patient isnt stuck every time they turn around, which is important. Again, the chemo damages the veins, and many cancer patients have a really hard time getting regular IVs. They can draw blood with it too.

If he goes through the transplant and uses his own stem cells, I am pretty sure they can harvest peripheral blood stem cells with the hickman too. Its done the same way giving plasma is done, but using the hickman would allow them to do it without the large needles in the arm.
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Is chronic myloid leukemia curable?

Postby fridgeir » Sun Apr 10, 2011 3:47 am

It depends.

Some patients will go on oral medication for their CML, and if it works, they can stay on medication for their entire natural lifetime without the disease progressing. This is living with cancer, not a cure, but for many people with CML on modern philadelphia translocation treating medications, CML is merely an annoying chronic illness.

Some people with CML require a bone marrow or stem cell transplant. This has much greater risks than oral medication, but also greater benefits. After transplant, a person can become and stay philadelphia chromosome negative for the rest of their lives, or be entirely cured.

Talk to your friend about where his disease is and what sort of treatment you can expect him to be in.
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Is chronic myloid leukemia curable?

Postby delany » Sun Apr 10, 2011 3:51 am

The factors that influence the prognosis of patients include age,symptoms,type of leukemia
,stage, clinical and laboratory indicators, response to drugs,size of the spleen/liver,general fitness of the patient,avoidance of the complications and many more.

Each patient responds differently to the disease and the treatment that it is near-impossible for the doctor to give a correct estimate of the prognosis.

Overall, treatment offers better chances for controlling the progress of CML are better.

In recent years,the prognosis of CML patients has improved significantly due to quicker diagnosis,better mode of treatment involving bone marrow transplant and inerferons and also due to better supportive health care. The expected median survival of 3 years has increased to 5years or more while the 5-year survival rate of less than 20% has significantly increased to 50-60%.

Read more: Chronic Myeloid Leukemia - Prognosis http://www.medindia.net/patients/patientinfo/chronic_myeloid_leukemia_prognosis.htm#ixzz16vS53mi8
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Is chronic myloid leukemia curable?

Postby birkir » Sun Apr 10, 2011 4:04 am

Chronic myelogenous leukemia (CML) is known as a myeloproliferative disorder—that is, it is a disease in which bone marrow cells proliferate (multiply) outside of the bone marrow tissue.

CML is easy to diagnose, since it has a genetic peculiarity, or marker, that is readily identifiable under a microscope. About 95% of CML patients have a genetic translocation between chromosomes 9 and 22 in their leukemic cells. This abnormality, which is known as the Philadelphia chromosome (Ph1), is named after the city in which it was discovered. The Philadelphia chromosome causes uncontrolled reproduction and proliferation of all types of white blood cells and platelets (blood clotting factors). Sadly, CML is not yet curable by standard methods of chemotherapy or immunotherapy.

CML tends to occur in middle- and retirement-aged people (the median age is 67 years). It occasionally affects people in their 20s, but it is rare in the very young; only 2% to 3% of childhood leukemias are CML. Early disease often is without symptoms (asymptomatic) and is discovered accidentally. Individuals with more advanced cases of CML may appear sickly and experience fevers, easy bruising, and bone pain. Laboratory and physical findings include enlarged spleen (splenomegaly), a high white blood cell count, and absent or low amounts of the white blood cell enzyme alkaline phosphatase.

Like other forms of leukemia, CML is not "staged". Rather, this unstable disease is categorized according to the three phases of its development: chronic, accelerated, and blast.


Chronic phase—Patients in this initial phase have fewer than 5% blast cells and promyelocytes (immature granulocytes) in their blood and bone marrow. This phase is marked by increasing overproduction of granulocytes. Individuals generally experience only mild symptoms, and they respond well to conventional treatment.
Accelerated phase—Patients in this progressive phase have more than 5%, but fewer than 30% blast cells. Their leukemic cells exhibit more chromosomal abnormalities besides the Philadelphia chromosome, and so more abnormal cells are produced. Noticeable symptoms such as fever, poor appetite, weight loss occur, and patients may not respond as well to therapy.
Blast phase (acute phase, blast crisis)—Patients in this final phase have more than 30% blast cells in their blood and bone marrow samples. The blast cells frequently invade other tissues and organs outside of the bone marrow. During this phase, the disease transforms into an aggressive, acute leukemia (70% acute myelogenous leukemia, 30% acute lymphocytic leukemia). If untreated, CML is fatal in roughly 20% of all patients each year.


And a hickman port is an IV catheter used to administer chemo
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