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How long does it take abnormal/pre cancerous cells with the HPV virus present, to turn into cancer?

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How long does it take abnormal/pre cancerous cells with the HPV virus present, to turn into cancer?

Postby jeevan59 » Sun Jun 10, 2012 10:57 am

I had a abnormal pap this past October and yesterday they did a Colposcy and took samples of the tissue and scraped the cells for a sample. The doctor said that she will can in a week in a half. How long do you think that it would take for the cells to change into cancer or do you think they have already since the HPV virus is present? Anyone who has been through this or knows anything about it, please help. I am VERY scared of the results.
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How long does it take abnormal/pre cancerous cells with the HPV virus present, to turn into cancer?

Postby rhys » Sun Jun 10, 2012 11:03 am

It depends on exactly what type of cell abnormalities were found. Some cell abnormalities are not cancerous. Some cells are somewhat likely to become cancer someday, some are very likely to become cancer in the near future, and some are in early stages of cancer (where they start to grow faster than normal cells). The possibilities range from never becoming cancerous, to becoming cancerous in months to decades even with HPV. A non-specific pap smear abnormality doesn't mean anything until you get the results of the biopsy.
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How long does it take abnormal/pre cancerous cells with the HPV virus present, to turn into cancer?

Postby custenhin » Sun Jun 10, 2012 11:14 am

Did your doctor call you of your biopsy report? Were the cell changes LGSIL or HGSIL. Other reporting system could use the CIN 1, 2 or 3 reporting.

It can take years or decades for abnormal cell changes to progress to cancer. LGSIL regress most of the time within a year or two. HGSIL could progress 50% of the time. HGSIL cell changes are treated and LGSIL cell changes usually are only monitored. Cervical Cancer is rare in the young woman.

Having HPV does not mean that the cell changes will persist or progress. In most women the virus does not progress. The virus is very common.

Routine Pap testing allows our doctor to monitor our cervix finding cell changes early and if they persist or progress a treatment removing the cell can be recommended which can prevent most all cervical cancers.Follow your doctor's recommended follow up for your Pap test. Your next Pap test may not show any signs of abnormal cell changes.

It is important to remember that abnormalities rarely become cancerous, and even severe lesions do not always lead to cancer.
Low-grade squamous intraepithelial lesions (LSILs) are considered mild abnormalities caused by HPV infection. Low-grade means that there are early changes in the size and shape of cells. Intraepithelial refers to the layer of cells that forms the surface of the cervix. LSILs are sometimes classified as mild dysplasia. LSILs may also be classified as cervical intraepithelial neoplasia (CIN-1).
High-grade squamous intraepithelial lesions (HSILs) are more severe abnormalities that have a higher likelihood of progressing to cancer if left untreated. High-grade means that there are more evident changes in the size and shape of the abnormal (precancerous) cells and that the cells look very different from normal cells. HSILs include lesions with moderate or severe dysplasia and carcinoma in situ (CIS). HSIL lesions are sometimes classified as CIN-2, CIN-3, or CIN-2/3. CIS is commonly included in the CIN-3 category.
The majority of HPV infections are self-limited and spontaneously clear within a several-year period as a result of cell-mediated immunity. In one study, two-thirds of adolescents infected with low-risk HPV types spontaneously cleared their infections by 12 months, as did over half of those infected with high-risk HPV types (FIGURE 1).5 By 23 months, more than 80% had cleared their HPV infections. In another follow-up study of adolescents and young women with LSIL, 91% of HPV-infected individuals cleared their infections after 36 months of follow-up.10 However, many women who spontaneously clear one specific type of HPV become infected with another HPV type. This is part of the reason that infection with multiple types of HPV is quite common in sexually active adolescents and young women.
Cervix cancer is rare in this country today because most women get regular Pap tests.

I was diagnosed several years ago. I was 48 at that time. I have had many colposcopies and biopsies. I have had two LEEP’s
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How long does it take abnormal/pre cancerous cells with the HPV virus present, to turn into cancer?

Postby beals » Sun Jun 10, 2012 11:25 am

It takes many months or years for solid tumor cancers to develop.
No solid tumor malignancy gets out of hand in a matter of a few weeks.
Only an acute leukemias can be trouble if there are delays of weeks.
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