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How Efective Is Erbitux For A Methastasic Bone Cancer? What Can I Expect?

Discussions relating to bone cancer symptoms, diagnosis, treatment and prognosis

How Efective Is Erbitux For A Methastasic Bone Cancer? What Can I Expect?

Postby Rowan » Mon Jun 26, 2017 1:02 am

The methastasic bone cancer is from an unknown primary without any organ compromised, till now we know his liver has cells but is working normally wihtout any simptom.
We have 2 years with this problem one looking for what was the desease and other one with the diagnosis. He is in good shape now, when he´s not in pain.
Rowan
 
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How Efective Is Erbitux For A Methastasic Bone Cancer? What Can I Expect?

Postby Colby » Mon Jun 26, 2017 1:06 am

Cetuximab (marketed under the name Erbitux) is used in metastatic colon cancer and is given concurrently with the chemotherapy drug irinotecan (Camptosar®), a form of chemotherapy that blocks the effect of DNA topoisomerase I, resulting in fatal damage to the DNA of affected cells. While there remains some scientific controversy on this, assessment for EGFR expression is required for use in Colorectal Cancer, but not in Head & Neck Cancer. It is best to refer to updated Prescription Information [2]. Cetuximab was approved by the FDA in March 2006[3] for use in combination with radiation therapy for treating squamous cell carcinoma of the head and neck (SCCHN) or as a single agent in patients who have had prior platinum-based therapy.

One of the side effects of Cetuximab therapy is the incidence of, possibly severe, acne-like rash. http://en.wikipedia.org/wiki/Cetuximab

Compared to radiation alone, cetuximab plus radiation therapy can nearly double the median survival in patients with a certain kind of head and neck cancer that has not spread to other parts of the body. However, further research is needed to know whether cetuximab plus radiation is more effective than the current standard of care (chemoradiotherapy using the drug cisplatin).
Colby
 
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How Efective Is Erbitux For A Methastasic Bone Cancer? What Can I Expect?

Postby Gottfried » Mon Jun 26, 2017 1:08 am

You have done a good job of providing information - far better than most questions on this site - but we cant see the scans or examine what must be palpable lymphadenopathy and there still is a great deal of missing information. What was the size of the primary breast mass? Can it still be palpated and measured? CT scans of chest and abdomen looking for lung and /or liver involvement? Bone Scan? Serum tumor markers? Serum chemistries. etc. Why would you want to use useless, unscientific, unproven homeopathic treatments? Some supplements can interfere with the effectiveness of the expensive chemotherapy drugs she is receiving. Of the three different combination chemotherapy treatments she has had so far, I like the Cyclophosphamide, 5FU, and Adriamycin best - but that is just my preference. There are many variations - many chemo drugs and regimens that have been used effectively for breast carcinomas. There is still Taxol or Herceptin to try. What has been the clinical response to the three treatments of chemotherapy already given? Have there been repeat scans or physical examination evidence of response? Many of those lymph nodes described on the PET scan must be easily palpable and measurable. Still so much missing information here. The doses seem OK. Why use tamoxifen when the primary carcinoma has negative hormonal receptors? But we should not be second guessing the medical oncologist who has all of the information and has seen this person. You should have the option of a real second opinion - not an internet query - if you are not happy with the care. "IF" this is truly "stage IV" breast carcinoma, the goal is not a cure. The goal is to gain as much quality survival time as possible. Stage IV metastatic breast carcinoma is not considered a curable malignancy - though some patients can do well for years. The oncologist should have explained this in detail. Even though ~six months were wasted on useless homeopathic treatment, this disease had likely spread already back in March when the primary breast mass was found, so the delay before appropriate scientific treatment has probably not been a difference maker here. We believe that most breast cancers have been growing for years before they are clinically detectable, so you need not have too many regrets about that 5-6 month delay. I would not suggest any homeopathic supplements while you are trying chemotherapy, but it would be a good idea to ask your oncologist what he thinks about this. We all have our own opinions. At the university medical centers where I received the 13 years of training to be a board certified cancer chemotherapy specialist, none of the professors or attending physicians thought highly of homeopathic remedies.
Gottfried
 
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How Efective Is Erbitux For A Methastasic Bone Cancer? What Can I Expect?

Postby Atteworthe » Mon Jun 26, 2017 1:09 am

The methastasic bone cancer is from an unknown primary without any organ compromised, till now we know his liver has cells but is working normally wihtout any simptom.

We have 2 years with this problem one looking for what was the desease and other one with the diagnosis. He is in good shape now, when he´s not in pain.
Atteworthe
 
Posts: 61
Joined: Fri Jan 03, 2014 12:36 pm

How Efective Is Erbitux For A Methastasic Bone Cancer? What Can I Expect?

Postby Gershom » Mon Jun 26, 2017 1:10 am

Bone cancer isn't the worst cancer out there so your kind of lucky. My grandmother died from pancreatic cancer. And bone cancer. But most of it was pancreatic cancer, shoot all of it was. She took that and she found it really worked good. She could actually walk (she had it her leg) up stairs. But yeah it worked pretty good.:)but she still died:(
Gershom
 
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How Efective Is Erbitux For A Methastasic Bone Cancer? What Can I Expect?

Postby Cynan » Mon Jun 26, 2017 1:11 am

Cancer of unknown primary site (CUP) can be difficult to recognize and difficult to treat. What has happened is that your cancer originated somewhere else, metastasized to the bone, and than the primary tumor for unknown reasons disappeared leaving only metastatic disease. Usually an oncologist will try to make some type of guess or determination where the cancer originated in order to move forward with treatment.

American Cancer Society: CUP http://www.cancer.org/docroot/CRI/conten...

ACS: How is CUP diagnosed http://www.cancer.org/docroot/CRI/conten...

ACS: Detailed Treatment Guide for CUP http://www.cancer.org/docroot/CRI/conten...

NCI: Carcinoma of Unknown Primary

http://www.cancer.gov/cancertopics/types/unknownprimary

Perhaps the selection to erbitux stems from the doctors idea of where the CUP originated from? Since it is used for colon cancer perhaps they feel the original malignancy started in the colon? If this is true than erbitux may work for you since it works well for those with metastatic colorectal cancer. You will need to ask your doctor these questions.

Stay strong.
Cynan
 
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