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Down syndrome patients are more likely to get leukemia than solid tumors, why? Which type of leukemia?

Leukemia and blood cancer discussion.

Down syndrome patients are more likely to get leukemia than solid tumors, why? Which type of leukemia?

Postby menzies » Wed May 22, 2013 8:05 am

chromosomal abnormality makes them about 15% more likely to get AML and ALL... but they're also more likely to survive it.
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Down syndrome patients are more likely to get leukemia than solid tumors, why? Which type of leukemia?

Postby ethelred » Wed May 22, 2013 8:17 am

I don't know the theory for why this happens. All I know is that Downs is due to a genetic abnormality and leukemia is associated with somewhat similar genetic abnormalities. These genetic abnormalities result in the manufacture of abnormal proteins inside the cell. However, how this all works together, I don't know.
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